MicroRNAs in Cardiac Development
نویسندگان
چکیده
منابع مشابه
Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies
Objective(s): MicroRNAs (miRNAs) are a subfamily of small noncoding RNAs that play a variety of roles in regulating gene expression in nearly all organisms. They affect different biological pathways by post-transcriptionally regulating mRNAs. Aside from miRNAs’ role in maintaining cellular homeostasis, their perturbation is related to several pathologic states and dis...
متن کاملRILEY SYMPOSIUM MicroRNAs in Cardiac Development
The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression, and heterozygous mutations of transcription factors have frequently been implicated in human cardiovascular malformations. A novel mechanism involving post-transcriptional regulation by small, noncoding microRNAs (miRNAs) has emerged as a central regulator of many cardiogenic...
متن کاملmicroRNAs in cardiac development and regeneration.
Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent studies have established critical functions for these tiny RNAs in almost every facet of cardiac development and dise...
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RATIONALE MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions. Because microRNAs are products of transcription, the potential exists for microRNAs that regulate transcription...
متن کاملThe role of microRNAs in cardiac development and regenerative capacity.
The mammalian heart has long been considered to be a postmitotic organ. It was thought that, in the postnatal period, the heart underwent a transition from hyperplasic growth (more cells) to hypertrophic growth (larger cells) due to the conversion of cardiomyocytes from a proliferative state to one of terminal differentiation. This hypothesis was gradually disproven, as data were published show...
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ژورنال
عنوان ژورنال: Pediatric Cardiology
سال: 2010
ISSN: 0172-0643,1432-1971
DOI: 10.1007/s00246-010-9639-3